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Mind & Body Solution for PMS

About Dr. Jarret Morrow:

Tomorrow, Dr. Jarret, MD is president and director scientist at the University Health Industries, Inc. Dr. Morrow received his Doctor of Medicine, University of Alberta in June 2001 and before that, he received his Bachelor in Science in Pharmacology with distinction, also from the University of Alberta, in June 1997. Dr. Morrow has been a distinguished presenter at numerous conferences worldwide scientific and medical, usually involving several areas of psychiatry, including anxiety disorders and physical effects of psychological stress, and has also co-authored numerous medical research publications in general, similar beings. Dr. Morrow is the inventor of two formulations of dietary supplements in patent pending ( updates dietary supplement ).

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Never disregard medical advice or delay in seeking medical advice or treatment because of something you have read on this site or the site of Industrial Health University ™.

Party 1: About PMS

1. What are PMS and PMDD?
2. What causes PMS?
3. What are the symptoms PMS?
4. What are the risks of premenstrual syndrome and premenstrual dysphoric disorder?
5. How I can know if I have have PMS?
6. What I can do to control my symptoms?
7. What medical treatments are available?
8. How effective are selective serotonin reuptake inhibitors (SSRIs) for treatment of premenstrual syndrome?
   What is the effectiveness of analogues of gonadotropin-releasing hormone (GnRHa) therapy in the treatment of premenstrual syndrome?
9. Bright light therapy is effective in treating of depression associated with premenstrual dysphoric disorder?

Part 2: On Zenstral

1. What is PMS ™ Zenstral?
2. Who should take Zenstral SPM ™?
3. What are the ingredients?
4. How Zenstral SPM ™?
5. What evidence-based medicine?
6. What is a meta-analysis?
7. What evidence science was used in the formulation of Zenstral SPM ™?
8. Who should not take Zenstral SPM ™?
9. How much should I take?
10. When will you start work?
11. What are the possible side effects?
12. What is the Program of TruLabel PAN?
13. What is your warranty?
14. Who's Industries of the University Health, Inc. (UHI)?
15. What other nutraceuticals are available at UHI?

Part 1: About PMS

Understanding PMS is one of the most important things you can do to control their symptoms. In this booklet, Jarret D. Morrow, MD, scientific director and president of the University of Industry Health, presents the facts about PMS, a summary of treatment options and ongoing independent research supports the use of SPM ™ to relieve Zenstral premenstrual syndrome and premenstrual dysphoric disorder.

What are PMS and PMDD?

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), a more severe form of premenstrual syndrome, are common and potentially debilitating conditions that many women suffer. Hormonal changes after ovulation trigger a disturbing set of symptoms appear about 14 days before your period. PMS and PMDD affects an estimated 40 million women in the United States, with more than 5 million require medical treatment.

What causes PMS?

Although the exact cause of PMS is not completely understood, it appears that the hormones progesterone, estrogen and testosterone are involved, along with changes in the level of the brain chemical serotonin. Nutritional deficiencies in magnesium and vitamin B6, hormonal changes, neurotransmitter activity, diet and stress have been implicated in the etiology of PMS.1, 2

What are the symptoms of PMS?

Most women feel some discomfort before their periods. But if you have PMS may feel so anxious, depressed or uncomfortable that you can not cope at home or at work. Common symptoms of PMS include:

The physical and psychological symptoms

• Breast tenderness (Breast pain)
• Irritability
• Cramps
• Angry outbursts
• Swollen hands or feet
• Low self-esteem
• Headaches
• Anxiety
• Weight gain
• Confusion
• Bloating
• Difficulty concentrating
• Constipation
• Mood swings
• Joint pain
• Episodes crying
• Fatigue
• Decreased libido
• Acne
• Depression

Symptoms usually stop or slow down quickly after your period starts, and may be free of symptoms until about two weeks before your next period.

What are the risks of PMD and PMDD?

PMS and PMDD are not mere inconveniences. These conditions may adversely affect personal success, professional and economic advancement of women. Women who suffer from PMS have an increased risk of depression, absenteeism, strained relations, reduced productivity, and worsening of medical conditions such as epilepsy, asthma, fibromyalgia, multiple sclerosis or migraine headache in the phases specific menstrual cycle.

How I can know if I have PMS?

According the American College of Obstetricians and Gynecologists (ACOG), can have PMS if

• PMS symptoms occur only during the last two weeks of your cycle.
• The symptoms are uncomfortable enough to impair their quality of life.
• other disorders that may be confused with PMS have been excluded.

If you suspect you have PMS, ACOG recommends keeping a diary of your symptoms for two or three consecutive months to help in diagnosis. It is important talk to your doctor to confirm diagnosis and rule out other possible causes of your symptoms, including depression, migraine headaches, seizures, bowel syndrome irritable, chronic fatigue syndrome, or allergies.

What I can do to control my symptoms of PMS?

Women often can control symptoms of premenstrual syndrome by making changes in the way we eat, exercise, and focus their daily lives. To reduce discomfort, try applying as many of the suggestions below as possible.

Dietary advice to control the SPM

• Eat small, frequent meals to reduce the swelling and the feeling of satiety.
• Eat carbohydrates complex as whole grain breads, pastas and cereals.
• Cut down on sugar and fat in your diet.
• Avoid salt for the last few days before your period to reduce the swelling and fluid retention.
• Avoid caffeine to feel less tense and irritable.
• Avoid alcoholic beverages. The consumption of alcohol before period can make you feel more depressed.
• Choose foods rich in calcium.
• Increased consumption of dietary fiber.

Lifestyle Tips for Managing PMS

• Get aerobic exercise. Regular daily exercise will help improve your overall health and can relieve symptoms such as fatigue and depressed mood.
• Ensuring adequate eight hours of sleep per night.
• Try to schedule stressful events for the week after your period.
• Maintain a regular schedule for eating, sleeping and exercise.
• Practice deep breathing exercises to help to reduce headaches, anxiety or trouble sleeping.
• Avoid cigarette smoking.

What medical treatments are available for PMS and PMDD?

There are four types of prescription drugs used for PMS and PMDD:

1. The antidepressants that act on serotonin, including fluoxetine, sertraline and paroxetine.The recently FDA ordered the manufacturers of antidepressants to issue warnings of black box that patients with these drugs should be closely monitored for "clinical worsening suicide, or unusual changes in behavior."
2. Agents inhibiting ovulation, such as danazol, estradiol, transdermal patches, and some oral contraceptives. These drugs carry risks of serious side effects can be very expensive.
3. Other psychotropic drugs to reduce anxiety, such as alprazolam benzodiazepines and other anxiolytics. From alprazolam has a short half-life life, you run the risk of addiction in patients who start this medicine.
4. Spironolactone, a diuretic that is available by prescription only care. It has been proven effective in reducing premenstrual water retention, but does not address the other symptoms of premenstrual syndrome.

How effective are selective reuptake inhibitors (SSRI) for the treatment of premenstrual syndrome?

SSRIs are a class of drugs used to treat depression, anxiety and personality disorders. Patients may experience many side effects the use of these medications as weight changes, increased anxiety, suicidal thoughts, and sexual dysfunction. A study published in the Cochrane Database concluded convincing evidence exists to support the use of selective inhibitors of serotonin reuptake in the management of severe premenstrual syndrome. However, withdrawals due to side effects were 2.5 times more likely to occur in the treatment group than in the placebo group.3

What is the effectiveness the use of analogs of gonadotropin-releasing hormone (GnRHa) to treat PMS?

GnRH analogues to stop work periods to decrease estrogen production. A recent meta-analysis published in the British Journal of Obstetrics and Gynecology concluded that treatment with GnRHa seems to be an option effective management PMS.4 Unfortunately, patients who take these analogues may experience some serious side effects, including type of menopause symptoms such as hot flashes, mood swings, vaginal dryness and increased LDL cholesterol and bone loss.

It is the bright light therapy effective in treating depression associated with premenstrual dysphoric disorder?

Light therapy involves exposure to full spectrum light for a certain amount of time. A recent meta-analysis of bright light therapy published in the American Journal of Obstetrics and Gynecology concluded that "current evidence does not justify a broadcast enthusiastic and confident about the rejection of this therapeutic modality. "5 In essence, this suggests that more research is needed to study the potential benefit of this treatment for PMS.

Part 2: About Zenstral ™ PMS

From University Health Industries

PMS Zenstral University Industries Health

Testimony:

"I want to thank you for all your help. I have had the most terrible PMS symptoms all possible. Zenstral PMS has made all the difference! I have none of the symptoms, no headaches, cramps, irritability, mood swings and pain. This works! Many thanks for this product! "

– W Debbie, North Carolina.

What is premenstrual syndrome Zenstral ™?

Zenstral SPM ™ is an innovative blend of natural compounds that are scientifically proven to reduce symptoms of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). Unlike other treatments for PMS, Zenstral both directions of the physical and psychological PMS / PMDD in a convenience product, without the risk of dangerous side effects.

Using the principles of evidence-based medicine, our doctors and SPM ™ Zenstral pharmacologists formulated after months of reviewing the results of university research studies worldwide. The result is a nutraceutical powerful that it is as effective as PMS and secure resources. †

Who should take Zenstral SPM ™?
SPM Zenstral ™ is recommended for women suffering from premenstrual syndrome symptoms related fromgeneral

• cyclical symptoms of mood PMS such as irritability, tension, depression
• lower back and joint pain associated with premenstrual syndrome
• retention fluid associated with premenstrual syndrome
• breast tenderness associated with premenstrual syndrome

What are the ingredients of Zenstral SPM ™?

Each capsule contains 20 mg of Vitex agnus castus (0.3 casticin%), 200 mg magnesium oxide (Mg), and 50 mg of vitamin B6 (pyridoxine) ..

The Vitex agnus castus (VAC), compound used in Zenstral is casticin, a flavonoid of Chasteberry. This is the same substance used in clinical studies that demonstrate Vitex agnus castus to be effective. Most other products on the market to standardize agnuside, terpene compound Chasteberry tree.

SPM ™ Zenstral How?

Natural compounds in the workplace Zenstral in many of the biochemical mechanisms that contribute to premenstrual syndrome: †

Vitex Agnus Castus Extract (VAC): Acts of VAC on the hypothalamic-pituitary-adrenal (HPA), a set of complex interactions between the three hormone-producing organs. It also reduces stress-induced and prolactin levels by simulating the effects of dopamine in the brain (dopamine agonist) 0.6 In addition, VAC has been found to increase beta-endorphin and levels of opioids, natural substances that reduce pain and create a sense of calm and wellbeing being.7, 8

Magnesium levels low magnesium in red blood cells have been correlated with symptoms of PMS.9 This is why magnesium supplementation has led to a series of studies magnesium supplements for women suffering from premenstrual syndrome.

Vitamin B6: Also called pyridoxine, vitamin B6 has a positive levels of neurotransmitters such as serontonin, norepinephrine, histamine, dopamine, and taurine.10

What is evidence-based medicine?

Evidence-based medicine (EBM) involves examining a wide range of evidence such as meta-analysis, systematic reviews of research existing randomized controlled trials, cohort studies and other research methods to make decisions about patient care and treatment.

MBE is quickly becoming the new paradigm in health care, replacing the old model based on authority, when the value of medical treatment (And sometimes availability) was based on the work of a limited number of experts.

For more information on evidence-based medicine, a nonprofit organization called the Cochrane Collaboration (www.cochrane.org) is an excellent place to start.

What is a meta-analysis?

A meta-analysis involves collecting data from many studies of similar research, then analyze the data collected for significance statistics.

What tests are used in the formulation of Zenstral SPM ™?

Below is a representative sample of the scientific evidence used in the formulation of SPM ™ Zenstral:

Extract Vitex Agnus castus (VAC)

A recent double-blind, randomized controlled trial published in the British Medical Journal showed a 52 percent reduction in PMS symptoms in women treated with the dry matter of agnus castus fruit.11 Similar results were obtained in another study published in the Archives of Gynecology and Obstetrics.12

Another recent study Vitex agnus castus are extract as effective as fluoxetine in the treatment of PMDD, a more severe form of premenstrual syndrome. The authors reported that 57.9 percent of patients responded to VAC extract in the treatment of this disorder, and also found that VAC extract was more effective than fluoxetine in the treatment of physical symptoms PMDD.13

German health authorities have approved the use of Chasteberry for three gynecologic conditions: menstrual cycle irregularity, premenstrual syndrome (PMS) and breast pain (chest pain) .14

Magnesium

A recent study randomized, double-blind concluded that magnesium works synergistically with vitamin B6 to relieve symptoms of anxiety associated with PMS.15

Vitamin B6

The British Medical Journal did a meta-analysis of vitamin B6 in the treatment of premenstrual syndrome and concluded that it was likely to be beneficial in the treatment of premenstrual symptoms and premenstrual depression.16

Who should not take Zenstral SPM ™?

Consult a physician before use if you are pregnant, nursing, birth control pills, have a medical condition such as hormone-sensitive breast cancer, or are taking dopamine-related drugs.

How should I take?

The typical dose is one capsule twice daily. Take Zenstral ™ every day of the month, not only when you are having symptoms. It is necessary to achieve and maintain therapeutic levels in the body work.

When will you start work?

With daily use, Zenstral ™ reach therapeutic levels in the system within three to four weeks, so you should feel relief at the second cycle. In contrast, prescription antidepressants take at least a month to start working and not address the physical symptoms of premenstrual syndrome.

What are the possible side effects?

There were no Serious side effects have been reported for ingredients in Zenstral SPM ™. Data from clinical trials, post-marketing surveillance studies, notification systems spontaneous, manufacturers and herbalist organizations indicate that compounds in Zenstral SPM ™ are generally well tolerated, and that any adverse event after treatment VAC are mild and reversible.17 Possible side effects include nausea, gastrointestinal upset, headache, or pruritus.11, 12,13,15,16,17,18

Browse a doctor if any of these side effects or using this product for over six months. Discontinue use and consult a doctor if an allergic reaction.

No drug interactions have been reported. However, due to Zenstral mode of action, consult your doctor before use if you are taking medication related to dopamine.

What is PAN TruLabel Program?

Natural Products Association (NPA) TruLabel program is the industry self-regulation program more comprehensive and successful.

Industries at the University of Health and other members of the Police Academy voluntarily pay for randomized controlled trials of their products by independent laboratories. If the test reveals a deficiency in product quality or accuracy in labeling, warning NPA member company immediately and expected to take corrective action. ANP revoke the membership of any company that does not comply.

What is your warranty?

products of University Health Industries is backed by our 100% guarantee money back orders for the first time. If for any reason you are not completely satisfied with your order, simply return it within 30 days and we will issue a full refund of the price purchase, minus shipping and handling.

Who's Industries of the University Health, Inc?

Each year, research laboratories worldwide to identify and test natural compounds with potential to improve human health and yet more than 98% of these discoveries not traded in the public interest.

University Health Industries, Inc. (OTC: UVHI), in collaboration with universities around the world, research natural compounds with clinically proven efficacy, identifies those with the greatest potential to improve human life, and then become proprietary nutraceuticals common treatment for chronic diseases.

Our mission is to make the latest clinical findings on available natural compounds consumers, delivered in patented pharmaceutical-grade formulations with guaranteed quality and potency.

UHI is a pride of America, with offices and manufacturing facilities in Boca Raton, Florida. All our products are approved by GMP and made in the United States to ensure that they adhere to the rules of the opinion American public can trust.

What other nutraceuticals are available at UHI?

UHI will introduce three new products in the coming weeks, each developed with the same quality and performance standards as Zenstral SPM ™:

• Arthroleve ULT ™ for bone and joint pain †
• † ™ ULT same premium to support mood
• Cold & Flu RMD ™ for immune system support and relief of common cold †

References

1 J. Mortola Premenstrual syndrome-pathophysiologic considerations. N Engl J Med 1998, 338:256-7.

2 Chrousos GP, Torpy DJ, Gold PW. Interactions between the hypothalamic-pituitary-adrenal and female reproductive system: clinical implications. Ann Intern Med 1998, 129:229-40.

3 KM Wyatt, PW Dimmock, PM O'Brien. Selective inhibitors of serotonin reuptake for premenstrual syndrome. Base Cochrane Database Syst Rev. 2002; (4): CD 001,396.

4 Wyatt KM, Dimmock PW, Ismail KM, Jones PW, PM O'Brien. The effectiveness of GnRHa with and without "add-back therapy in the treatment of premenstrual syndrome: a meta-analysis. BJOG, 2004 Jun, 111 (6) :585-93.

5 Krasnik C, Montori VM, Guyatt GH, Heels-Ansdell, D Brusse JW, Study of medically unexplained syndromes Group. The effect of bright light therapy on depression associated with premenstrual dysphoric disorder. I J Gynecol. 2005 Sep; 193 (3 Pt 1) :658-61.

6 Merz PG, C Gorkow, Schordter A Rietbrock S, C Sider, Loew D, Dericks-Tan JSE, Taubert HD. Special effects Agnus castus extract (BP 109E1) on prolactin secretion in healthy male subjects. Clin Exp Endocrinol Diabetes. 1996, 104:447-53.

7 R Brugisser, Burkard W, Simmen U, Schaffner W. Untersuchungen an opioid-Rezeptorin MIT Vitex agnus-castus L. Z Phytother. 1999, 20:140-58.

8 Samochowic L, R Glaesmer, J. Samochowic EifluBvon auf die Konzentration von Monchspfeffer im serum beta-endorphin weiblicher Ratten. Arztez Naturheilverfahren. 1998, 39:213-215.

9 Rosenstein DL, Elin RJ, Hosseini JM, et al. Magnesium measures across the life menstrual premenstrual women. Biol Psychiatry. 1994, 35:557-61.

10 Schindler R, H Thoni, HG Classen. The role of magnesium in the generation and treatment of benign muscle cramps. Combined in vivo / in vitro studies on preparations of the phrenic nerve of the diaphragm. Arneimittel-Forschung. 1998, 48:161-66.

11 Schellenberg, et al. The treatment for premenstrual syndrome with agnus castus fruit extract: prospective, randomized placebo and controlled. BMJ. 2001, 322 and 134-7

12 Berger D, Schaffner W, Schrader E, Meier B, Brattström A. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet. 2000, 264:150-53.

13 Atmaca M, K Selahattin, Texc E. fluoxetine Vitex agnus castus extract against the treatment of premenstrual dysphoric disorder. Human Psychopharmacol Clin Exp. 2003; 18:191-5.

14 million Blumenthal, Busse WR, Goldberg A, et al. The German Commission E. Full monographs: therapeutic guide to herbal medicines. Austin TX. Botanical Council of America. 1998, p1694.

15 M De Souza, Walker A, Robinson P, Bolland K. synergistic effect of daily supplementation of 1 month from 200 mg magnesium plus 50 mg of vitamin B6 for the relief of premenstrual symptoms related to anxiety: a randomized, double-blind crossover. Women's Health Journal and gender-based medicine. 2000 Mar; 9 (2), 131-3.

16 Wyatt K, Dimmock P, P Jones, PM Shaughn O'Brien. The effectiveness of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ. 1999, 318:1375-81.

17 C Daniele Thompson J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf. 2005, 28 (4) :319-32.

18 Walker A, De Souza M, M Vickers, S Abeyasekera, Collins, M, L. Trinca magnesium supplementation alleviates premenstrual symptoms of fluid retention. Journal of Women's Health. 1998 Nov; 7 (9) :1157-65.

19 Proctor M, P. Murphy herbal therapies Dietary advice for primary and secondary dysmenorrhoea (Cochrane Review translated). The Cochrane Library, Issue 2, 2002. Oxford: Update software.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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